Superresolving, Artifact-Free Optical Coherence Tomography with Deconvolution-Random Phase Modulation

Deconvolution is widely used to improve resolution in microscopy. Unfortunately, deconvolution optical coherence tomography (OCT) sensitive noise which inherently results additive artifacts. These artifacts severely impair the fidelity of deconvolved images and limit its use OCT imaging. Here we propose a framework that encodes numerical random phase masks Fourier space image, produce sub-resolution image with removed. The optimized joint operation an iterative Richardson-Lucy synthesis (RPM), termed as Deconv-RPM, enables 2.7-fold enhancement both transverse axial resolutions. We demonstrate Deconv-RPM method allows imaging previously unresolved cellular-level details human labial mucosa vivo significantly improved clarity.